The Xinjia Express Hotel in Quanzhou collapsed just after 7pm, according to Mnw.cn, an online news site operated by the official Fujian Daily.
Authorities in Licheng district said about 70 people were in the building when it collapsed.
The Quanzhou municipal government said 34 people had been rescued by about 10pm.
The Beijing News quoted several local government officials as confirming the hotel had been turned into a quarantine centre and was one of two in the district. The exact number of people in the building at the time was unknown.
People’s Daily reported that the hotel had been converted by the Licheng district government into a medical surveillance facility for people with close contact with coronavirus patients.
A man living across the road from the hotel said he thought the collapse was an explosion.
“I was just having dinner and I suddenly heard a loud bang and thought it was an explosion. It was not until I ran to my balcony that I saw that the entire hotel building had collapsed,” Mnw.cn quoted the man as saying.